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It is therefore possible that oxidant stress reduces remethylation and enhances transsulfuration to maintain, via an autocorrective process, the intracellular glutathione pool, which would be essential for the redox-regulating capacity of cells

The BTB and IVR domains are required for the redox- and electrophile-sensitive regulation of Nrf2 through a series of reactive cysteines [113-115]

Sarris AH, Viviani S, Bonfante V, Kliche KO, Notti P, Peethambaram P, Tucker S, Preti A, Mesina O, Hagemeister F, Romaguera J, McLaughlin P, Rodriguez MA, Andreeff M , Witzig T, Bonadonna G, Cabanillas F

These results raise questions about the actual therapeutic window for GlyT1 inhibition, especially regarding duration, dose, and the regional specificity of transporter modulation

Brain Res 1004: 193197, 2004

Studies on the evaluation of the association between GPx1 and atherosclerosis variants in Japanese patients with type 2 diabetes, with four polymorphisms, reported that functional variants of the GPx1 gene are associated with increased mean intima-media (IMT) thickness of carotid arteries and cardiovascular risk and peripheral vascular disease in type 2 diabetics [63]