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The controversial outcomes of mTOR inhibitors in sepsis clinical trials highlights the extreme importance of the intervention timing and immune-metabolic stratification of patients-inhibiting mTOR during the immunosuppressive stage may further impair T-cell function and exacerbate the condition (56)

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Thromb Res 110(23):8791 Orzechowska-Pawilojc A, Sworczak K, Lewczuk A, Babinska A (2007) Homocysteine, folate and cobalamin levels in hypothyroid women before and after treatment

The cellular and extracellular GS-B contents were determined as described previously [37, 38]