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Sleep deprivation significantly impacts AT function and adipokine secretion patterns

Following detoxification of NAPQI, the cysteine and mercapturic acid conjugates produced are excreted

Under normal physiological conditions, Keap1, as the substrate adaptor of the E3 ubiquitin ligase complex, maintains intracellular redox balance by promoting the ubiquitination and degradation of Nrf2

All these indicated that stress factors, actively growing tissues as well as normal physiological and metabolic changes could induce the expression of APX genes in tissue-dependent way