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CVD is a common comorbidity of AS and other SpA diseases, and TMPO may provide new insights into the underlying mechanisms and interventions associated with AS

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thereby, stroke generally requires the support of the healthcare system (10)

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In addition, more and more studies have confirmed that AH patients and animals are often accompanied by abnormal bile acid metabolism, which affects the integrity of the intestinal barrier and is closely related to the poor prognosis of the disease (Way et al., 2022)

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