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Description

A drug is assumed to be uniformly distributed within a compartment and can move dynamically in and out of compartments

Vrdoljak J, Kumric M, Vilovic M, Martinovic D, Tomic IJ, Krnic M

Low glutathione in a disease is not proof of replacement therapy A biomarker can be a cause, a consequence or an accompanying feature of disease

Still, COMT status is a major piece of the puzzle that can explain long-standing quirks

To support efficient detoxification and transformation in the liver, a sealed, balanced gut is key

APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury