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In this Review, we trace the recent evolution of obesity pharmacotherapy from GLP1 receptor agonists to next-generation multi-receptor agonists, alongside strategies that incorporate oral formulations, weight-loss quality approaches and tissue-specific drug targeting

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Phase Cag introduction Weeks 9-12 Retatrutide 4 mg/week (hold) Cagrilintide 0.25 mg/week Notes Add cagrilintide at the lowest dose

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