Copper is classified as a weak sensitizer far weaker than nickel and frank copper contact allergy is documented but uncommon
Possible Side Effects Side effects are uncommon but may include mild soreness at the injection site or a temporary headache

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Norepinephrine dysregulates the immune response and compromises host defense during sepsis
While we understand the comment that MRFs may not be primarily intended for direct patient use, we disagree that they have little utility for patients and the public