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292 , L1182L1192 (2007)

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Tumor necrosis factor (TNF) is a core inflammatory factor in RA, which inhibits phosphatase and tensin homologue-induced kinase 1 (PINK1)-mediated mitophagy and elicits mitochondrial damage, which increases cytoplasmic mtDNA levels and activates cGAS-STING, boosting inflammation in RA (105) (Figure 2)

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Furthermore, Acsm3 knockout mice showed glucose and lipid metabolic abnormalities, and hepatic accumulation of the ACSM3 fatty acid substrate lauric acid