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Our study explores the molecular mechanisms whereby PFOS/PFHxS disrupt liver metabolism and facilitate NAFLD development

Sequencing was performed on the Illumina platform Novaseq X Plus at the Northwestern University NUSeq sequencing facility core, with a targeted sequencing depth of 20,000 and 25,000 reads per sample acquired for RNA and ATAC profiling, respectively

Results obtained showed that the double knockdown of Dmrt3 and Dmrta2 upregulates the expression of proneural genes such as Neurog2 or Neurod1 that act as the primary initiators of neuronal differentiation and are directly activated by Pax6 , while the additional knockdown of Pax6 in Dmrt3

74 Powell-BraxtonL.HollingsheadP.WarburtonC.DowdM.Pitts- MeekS.DaltonD.et al (1993)