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CB1 antagonists block the interaction of endocannabinoids, such as the endogenous CB1 agonist anandamide, with CB1 receptors by binding to the CB1 receptor

Studied for effects on glucose tolerance and insulin response in preclinical models of metabolic syndrome

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Glucose trafficking through coupled astrocytes is necessary for hyperactivity, while extracellular glucose deprivation causes loss of synaptic hyperactivity that can be rescued when astrocytes are filled with glucose or lactate, showing the importance of metabolism in epilepsy formation

DCL1, along with two helper proteins, HYPONASTIC LEAVES 1(HYL1) and SERRATE (SE), forms the Microprocessor complex, which cuts pri miRNAs into shorter precursors (pre miRNAs) and then into small double-stranded miRNA/miRNA duplexes with short 3 overhangs