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We are very grateful to the editor and reviewers for critically evaluating the manuscript and providing constructive comments for its improvement

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We determined the initial values of the flux estimate as follows

Leveraging genetic and epigenetic data holds great promise for the development of precision medicine strategies in the context of mitochondrial dysfunction [33, 34]

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Disclosures: Raghav Bassi: Nothing to Disclose, Zubair Bodla: Nothing to Disclose, Mariam Hashmi: Nothing to Disclose, Fatima Niaz: Nothing to Disclose, Muhammad Khalil: Nothing to Disclose, Yaseen Perbtani: Nothing to Disclose, Tony Brar: Nothing to Disclose 1676 ACTIVITY METRICS MEASURED BY WEARABLE TECHNOLOGY CORRELATES WITH PATIENT-REPORTED WELLBEING IN CIRRHOSIS Brian McSteen 1 Jessica Siguencia 1 Russell Rosenblatt 2 Arun Jesudian 2 Ana Krieger 2 Avesh Thuluvath 3 Robert Schwartz 4 Robert Brown 2 Adam Buckholz 5 , 1 NewYork-Presbyterian, Weill Cornell Campus, 2 Weill Cornell Medicine, 3 Northwestern University Feinberg School of Medicine, 4 Weill Cornell Medical College, 5 New York Presbyterian Hospital Program Background: Inactivity is associated with progressive sarcopenia, worse transplant outcomes and increased mortality in cirrhosis