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Conclusions In ICU patients with sepsis-associated delirium, thiamine supplementation was associated with lower 30-day mortality and remained consistent across multiple propensity score-based analyses

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Thus, the existence of a specific transporter for exogenous ERGO in various organs implies that ERGO plays multiple physiological roles in various organs and may be useful for preserving physical and mental health

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Notably, a decrease in glutathione in the PPP may also result in the accumulation of ROS that trigger oxidative stress, causing inflammation and possibly contributing to the worsening of depression (Ozaslan et al., 2019)