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227 In comparison with the healthy population, MDD patients have a much higher incidence and prevalence of chronic liver disease

An increasing body of evidence suggests that disturbances in the pulmonary mechanical microenvironment, a complex interplay of extracellular matrix (ECM) stiffness, alveolar surface tension, cellular forces, and cell-matrix interactions, play a crucial role in the pathogenesis and progression of these diseases ( Owing to their unique size and highly tunable physicochemical properties, nanomaterials present unparalleled opportunities to finely adjust the pathological microenvironment within the lungs ( Here, we explore how nanomaterials can address dysregulation in the lungs mechanical microenvironment by modulating ECM properties, normalizing alveolar surface tension, and influencing mechanotransduction pathways in pertinent lung cells

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A possible explanation is that maintaining concentrations in great excess above required function may be an evolutionary protective or safety function, In this case, it would take time for enzymatic consequences, and deficiency, to develop if intake suddenly stopped

doi:10.1186/s12906-018-2101-4

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