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Chen Q, Hao W, Xiao C, Wang R, Xu X, Lu H, et al

Clinical trial design This was an investigator-initiated, phase 2, open-label, single-arm trial testing the efficacy of combination nivolumab plus ipilimumab in patients with locally advanced or metastatic RMC

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The electron transport chain (ETC) is a continuous reaction system consisting of four membrane protein complexes and lipid-soluble electron carriers in a certain order, used to convert the reduction potential into a proton gradient across the membrane, accompanied by electron transfer to bind to oxygen molecules and produce water and generate adenosine triphosphate (ATP) for energy

GST-, MBP-, and SUMO-tags are three affinity tags that help solubilize recombinant proteins