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Excessive formation of reactive oxygen and nitrogen species leads to damage to proteins, lipids, DNA and RNA

Core Ingredient: Glutathione

[DOI] [PubMed] [Google Scholar] Schiborr C

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Together, these data suggest a model of how ROS generated in mitochondrial compartments can spread throughout a cell on a minute timescale

Then the resin was loaded on a glass column and slowly washed with wash buffer containing 160 g/ml benzamidine, 100 g/ml leupeptin, 15 mM imidazole, and 1 M PF-05190457 for gradually exchanging to LMNG