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Moreover, macrophage infiltration in WAT and mRNA levels of the inflammation markers MCP1, F4/80, and TNF were found to be diminished in two mouse models of partial leptin deficiency (OBHZ and LepHZ mice), after a chronic high-fat (HF) diet feeding, suggesting that lower leptin levels within an obesogenic environment may be beneficial for obesity and insulin development prevention [140]

DOI:10.1093/nar/gkx989 Riccardi, L., Genna, V

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Once situated in the cytosolic compartment, the activated eNOS catalyzes the transformation of L-arginine into NO

Drug repurposing offers a cheaper and faster route through early clinical trials as ADMET information is available, creating a major advantage for orphan diseases such as ALS