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doi: 10.1007/s00429-014-0716-x, 23

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Yes, a prescription is required from your physician to order Cyanocobalamin 1000 mcg/ml

Physicians may opt to treat these patients and monitor for improvement of metabolic markers, particularly in populations at high risk of clinical vitamin B 12 deficiency, or observe these patients and periodically reassess their levels of vitamin B 12 , homocysteine, and/or methylmalonic acid

With 2 mL, the same 0.1 mL is only a 5% loss