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Erastin, a ferroptosis inducer, binds to VDAC2 and VDAC3 on the outer mitochondrial membrane, inducing mitochondrial dysfunction and oxidant release, ultimately triggering ferroptosis in tumor cells

Discussion Despite the evolution of EGFR mutation-targeting tyrosine kinase inhibitors (TKIs) through several generations, clinical challenges persist, including primary and acquired resistance, as well as a lack of response to therapy in EGFR wild-type cases

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Transthyretin (TTR), an abundant CSF protein, contains both free and oxidized Cys residues

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, etc., have significant vasodilatory bioactivities in vitro , but the hypotensive efffect of only 40% of TMPs have been investigated in vivo at present, such as G