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Barker, 2019)

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Oxidative stress: NRF2 induces antioxidant genes that reduce oxidative stress by minimizing the levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) (Ma, 2013)

The intestinal mucus layer prevents the entry of pathogens, the available adaptive and innate immune components in the mucosa, the transportation of antibodies by the polymeric Ig receptor and the diverse beneficial microbial flora improve the hosts physiological homeostasis (Simn et al., 2021)