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It is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m, should not be initiated in patients with an eGFR between 30-45 mL/min/1.73 m, and requires at least annual monitoring of renal function

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Individual paired samples are shown for participant age and days from initial acute COVID-19 infection (dfso)

A ligature was placed around the cervix of the lower left first molar as described in Materials and Methods in 36 rats to induce unilateral periodontitis