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Balshaw T, et al

As a result, the findings might not fully reflect the conditions of vascular ECs in different organs and tissues in vivo

Given the mechanism of enzyme inhibition, our non-covalent inhibitors can be targeted to TrxR and can be applicable to development of therapeutics for a broad range of diseases

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In contrast, pathways involved in metabolism, such as alanine, aspartate, and glutamate metabolism, biosynthesis of secondary metabolites, and C5-branched dibasic acid metabolism, displayed a balance of upregulated and downregulated genes

It is also an important thiol buffer, maintaining sulfhydryl groups in their reduced form, an additional mechanism for cellular signaling