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Most of these cancer cells lack VHL function, resulting in constitutive HIF expression

Orphanet J Rare Dis 16 , 446 (2021)

This has been hypothesized as either due to blood bacteremia from oral pathogens entering the blood via the bleeding gums and thus crossing of the blood brain barrier and/or entry to the brain via the trigeminal nerves (Teixeira et al., 2017

Additionally, the composite also doesnt exhibit structural and phenotypic anomalies, apoptosis, or gut necrosis, indicating that they are safe to be used in biomedical and environmental applications [193]