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In an adequately powered placebo-controlled RCT, which was the only report included in a published Cochrane review [396], a six-week course of pregabalin (n = 218) compared to placebo (n = 106) did not result in a significant reduction of NIH-CPSI total score [397]

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A good interventional study needs these three key features: Randomized (i.e., participants were randomly assorted into different groups, rather than hand-picked) Blinded (i.e., both researchers and participants dont know whos getting the treatment) Controlled (i.e., theres a placebo group and/or a treatment-control group to compare against) If an interventional study is missing just one of these features, the results can be manipulated to get almost any result the researchers want

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38 GTEx Consortium (2015)