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Further, through recent prior rulemaking (see, for example, 88 FR 79185 and 79195) we have refined the financial methodology to support ACOs serving medically complex, high-costs populations, such as the policy to cap regional risk score growth in an ACO's regional service area when calculating regional trends used to update the historical benchmark at the time of financial reconciliation for symmetry with the cap on ACO risk score growth according to 425.652(b)(2), and the policy to eliminate negative regional adjustments

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Receptor-Binding Studies: Used to evaluate receptor responsiveness and downstream signaling activation under defined experimental conditions