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Am J Physiol-Renal Physiol 283, F20F28 (2002)

History of surgical debridement, anticentromere antibody, and disease duration are associated with calcinosis in patients with systemic sclerosis

Results maintenance requires ongoing or periodic use - stopping treatment leads to gradual regression over 2-6 months as new collagen formation stops and natural aging resumes

It promotes tissue fibrosis by binding to PDGF receptors, while excessive ECM deposition exacerbates vascular lesions and hypoxia, further aggravating fibrosis (162, 164, 165)

They went on to state that glutathione (GSH) can reduce oxidative stress (inflammation) by fighting the formation of damaging free radicals in the reproductive system

Dosages are patient-specific but generally fall within a well-established therapeutic window