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38 Iron overload Although iron is a helpful component of the human body and the major micronutrient in the human diet, involved in crucial cellular functions and metabolic processes, excessive iron increases the production of ROS, leading to cell dysfunction or death, tissue damage, and organ disease

However, GSH may reduce lipid accumulation by regulating lipid metabolism gene expression (Chen et al., 2025), thereby showing a better hepatopancreas structure

Besides GPX4 and SLC7A11 in the present study, ferroportin (SLC40A1), a protein responsible for the outflux of iron from cell, as well as a heavy chain of ferritin (FTH1), the key cytoplasmic iron storage protein, is also controlled by Nrf2

Mesenchymal stem cells and immunomodulation: current status and future prospects