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Finally, r 1 and r 2 are random values that range from 0 to 1and they were taken in the MATLAB code as 1

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Pharmaceutics 14(12):2605 Han H, Li S, Xu M, Zhong Y, Fan W, Xu J et al (2023) Polymer- and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives