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Studies using skin fibroblasts derived from such Fabry patient biopsies showed a reduced respiratory chain enzyme activity, along with a reduction of energy-rich phosphates AMP, ADP and CP, indicating an impaired mitochondrial energy supply and that this can play a role in the pathogenesis of Fabry disease through a proposed change in the properties of the mitochondria membrane [38], further implicating the mitochondrial dysfunction as part of the symptoms

Biointerfaces 323 SperlingR.SallowayS.BrooksD

In cognitive disorders, the research has been focusing on exploring the effects of ALC since the 1980s, although the studies were relatively small, uncontrolled, and often unpublished

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Chaturvedi V, Wong B, Newman SL

It is also proposed that aromatic amino acids, such as tryptophan, which are sensitive to oxidation, can be attacked by ROS, such as OH radicals or atomic oxygen (Tolouie et al