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Development of polymeric nanoparticles for blood-brain barrier transfer-strategies and challenges

[00148] As used herein, the term "acyl" refers to a radical formed by removal of a hydroxyl group from an organic acid and has the general formula -C(0)-X where X is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted hetero arylalkyl as defined herein

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The ability of vitamin E to reduce the infiltration of neurotoxic proteins such as fibrinogen and thrombin into the brain has been linked to decreased neuroinflammation and improved cognitive outcomes in animal models of AD [54,229,230]