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doi: 10.1016/j.molp.2017.03.010 33 ChenP.ChenT.LiZ.JiaR.LuoD.TangM.et al

Defects in CI are among the most common causes of mitochondrial disorders and have been linked to a wide range of pathologies, including neurodegenerative and cardiac diseases 28

Administration of ISO results in elevated levels of intracellular Fe 2+ , ROS, and malondialdehyde (MDA)

29 When it comes to considering even higher doses of NAC, another study showed that oral administration of 1200 mg of NAC significantly reduced oxidative bursts from neutrophils induced by the stimulants C

10.18053/jctres.03.2017S1.002 J

In this case the fungal antioxidation system would be overwhelmed because levels of antioxidation enzymes would not be sufficient for detoxification of the concerted activities of multiple oxidative stress agents ( e.g ., oxidative stress drug + redox-active chemosensitizers)