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Finally, in PD patients we observed a decrease in both kynurenine and tryptophan levels, key metabolites in the tryptophan-kynurenine pathway, which is crucial for neuroprotection and immune modulation 33

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For instance, in prokaryotes, GSR is found in the periplasm [13,14], while in eukaryotes, it is found in the mitochondria, cytosol, endoplasmic reticulum and nucleus [1517]

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