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Outcomes were measured using PROMIS T-scoresvalidated, widely used patient-reported outcome instruments: Pain Intensity: 65.0 58.7 ( 6.3, p 98 percent purity via HPLC/MS, third-party testing for heavy metals and microbial contamination, and documentation of raw material endotoxin levels

Rozanowska M, Edge R, Land EJ, Navaratnam S, Sarna T, Truscott TG

Gonzalez, M

A key mechanistic insight is that IL-6 upregulates hepcidin, which promotes transferrin degradation and amplifies the vicious cycle of iron overload (Burton et al., 2020) (Figure 3D)