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Simultaneous inhibition of CXCR1/2, TGF-beta, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

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The Angiotensin IV/AT4 system has cerebroprotective effects (Wright, Clemens et al

61 Moreover, significant downregulation of the brain metastatic lncRNA suppressor X-inactive-specific transcript (XIST) in metastatic tumour cells leads to augmented secretion by these cells of exosomal miRNA-503, which triggers M2 polarisation and the accumulation in microglia of immune-suppressive cytokines, subsequently inhibiting T-cell proliferation

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