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However, in cases of primary failure, a switch to a non-anti-TNF- bDMARD might be more efficacious than swapping to another anti-TNF- [126], especially for seropositive RA patients (in favor of rituximab) and in those under bDMARD monotherapy (in favor of tocilizumab) [127]

First, mAbs are produced in eukaryotic cell lines because of their complex expression and post-translational modifications, increasing the cost of production [105]

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