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As a dietary supplement, take 1 capsule daily, or as directed by your healthcare practitioner

Initial doses of 125-250 mcg daily allow assessment of individual response and tolerance

Stimulating effect: Some users report mild over-stimulation or difficulty sleeping if dosed late in the day

Genome Med 2015;7, 106, doi:10.1186/s13073-015-0232-5

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Despite encouraging preclinical data, translating GPR109A-targeted therapies into clinical practice requires further investigation