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Platinum-induced peripheral neurotoxicity: from pathogenesis to treatment

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The echocardiogram will usually show more details as well, including sagging or stretching of the mitral valve, or even leakage (mitral regurgitation)

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This indicates that the PARK2 knockout model is characterized by increased -oxidation, mitochondrial dysfunction, oxidative stress, reactive microglia/macrophages, and inflammation in the midbrain