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10.1093/toxsci/49.2.156 Toxicol

The molecular size of hyaluronic acid is typically too large to penetrate deeply into the bloodstream when applied topically

In addition, the antioxidant trials in AMS should incorporate the measurement of plasma or another sample antioxidant levels, PK-guided dosing strategies tailored to hypobaric hypoxia conditions, consideration of BBB penetration for centrally mediated symptoms and longer pre-acclimatization supplementation periods

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