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For example, Plekhf1 was found to promote macrophage M2 polarization and increase pulmonary fibrosis through PI3K/AKT signaling

[DOI] [PubMed] [Google Scholar] 69.Grill E., Winnacker E.L., Zenk M.H

In membrane models comprising two lipid classes with similar acyl chain compositions, such as POPC/1-stearoyl-2-linoleoyl- sn -glycero-3-phosphoethanolamine (SLPE), POPC/1-stearoyl-2-linoleoyl- sn -glycero-3-phosphoglycerol (SLPG), and POPC/1-stearoyl-2-stearoyl- sn -glycero-3-phosphoserine (SLPS) (4:1 in all cases), in which acyl transfer from the sn -1 and sn -2 positions of each lipid class can be distinguished, acyl transfer is seen from both the lipid classes in accordance with their relative abundance, with no appreciable selectivity between reactivity at the sn -1 and sn -2 positions (Figure 4)

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Immunofluorescence (IF) showed a reduction in Col2a1 synthesis and an upregulation in Mmp13 expression in chondrocytes following the palmitate treatment (Fig

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