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Cytotoxic edema is partly associated with the early release of glutamate and accumulation of ions and osmotically active solutes, and with failure of the active ion pumps in the neurons and glia

Ruxolitinib (Opzelura) A topical JAK inhibitor that was approved by the FDA in 2022 as the first treatment specifically for repigmentation in vitiligo

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This occurs in peripheral circulation and can promote symptoms such as postural orthostatic tachycardia syndrome (PoTS), PEM, fatigue, endothelial cell dysfunction, platelet hyperactivation, mast cell activation, and connective tissue disorders

Gastroenterology 115:182205 Shanahan F (2000) Probiotics and inflammatory bowel disease: is there a scientific rationale