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Moreover, oxidative damage to mitochondrial DNA (mtDNA) results in the release of mtDNA into the cytosol, where it triggers Toll-like receptor 9 (TLR9) and inflammasome activation, leading to further production of pro-inflammatory cytokines and recruitment of immune cells 67

Over time, these repetitive movements put a strain on the medial common flexor tendons of the elbow, causing inflammation or microtears and degeneration in these tendons

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