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Description

Studies have proven that TLRs, MAPK, MyD88, CxCR4, PI3K/AKT, mTOR, COX-2, iNOS, Nrf2, HO-1, -enolase, STAT, AMPK, JAK, and NF-B signaling pathways are major components of NIF (248, 251, 252)

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doi: 10.3390/cells10030515 128 GuptaUGhoshSWallaceCTShangPXinYNairAPet al

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Scherholz ML, Schlesinger N, Androulakis IP (2019) Chronopharmacology of glucocorticoids

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It experimentally induced inflammatory reactions in the rat with the interference of eicosanoid formation in the arachidonic acid cascade (124) and could modulate the immune system as an anti-inflammatory factor ( Habashi and co-authors have also reported that bromelain potentially exerted anti-inflammatory effects by reducing nitric oxide synthesis in vitro without cytotoxicity (137)

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