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Aptamers-short, single-stranded oligonucleotides selected through systematic evolution of ligands by exponential enrichment (SELEX)-offer a powerful, flexible, and stable targeting modality ( We hypothesized that a fibrin-targeted, ROS-responsive GO nanocomposite encapsulating GSH (GO@GSH-FA) would selectively accumulate in ischemic brain regions and release its antioxidant payload in response to local oxidative stress

Addressing these knowledge gaps through genotype-stratified trials, the inclusion of advanced disease and co-infected cohorts, and transparent TRL mapping will be key to transitioning from promising proof-of-concept to clinically adoptable and affordable therapies [209,210,211]

They were then assigned to receive 600 mg of PEA plus 500 mg of acetyl-L-carnitine twice daily in addition to medical treatment or continue medical treatment alone for another 12 weeks

Bowers et al

[55] Alternative formulations or antiemetic agents may be necessary for these patients

This treatment offers an excellent introduction to glutathione therapy while maximizing vitamin C benefits for immune support and collagen synthesis