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Beyond deacetylation: the non-deacetylase functions of HDACs In addition to the protein deacetylation for HDACs, there are also several evidences showing that HDACs possess deacetylase-independent functions such as sumoylation, decrotonylation, ubiquitin-dependent function and lactylation eraser as shown below

Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors

Reduced eGFR is a potent marker for cardiovascular morbidity and mortality and should be regarded as a risk factor for cardiovascular disease, just like hypertension, cholesterol level and diabetic status

Acute VPA intoxication also occurs as a consequence of intentional or accidental overdose

Metabolic Constants and Plasticity of Cancer Cells in a Limiting Glucose and Glutamine Microenvironment-A Pyruvate Perspective

Consequently, inhalable heparin decoys were also developed to inhibit viral interaction with heparan sulfate on host cells 68,69