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470 Defective succinyl-CoA ligase not only hinders the TCA cycle by blocking the conversion of succinyl-CoA but also interferes with mitochondrial nucleotide salvage pathways by disrupting interactions with mitochondrial nucleotide diphosphate kinase, resulting in both metabolic dysfunction and mtDNA depletion

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Fiar Z, Hroudov J, Zvov M, Jirk R, Raboch J, Kitzlerov E (2023) Age-dependent alterations in platelet mitochondrial respiration

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