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The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]

Acknowledgements This research would not be possible without the generosity of people living with HIV and their OPERA caregivers

10.1038/nrurol.2014.194 11 BonizziG.PietteJ.SchoonbroodtS.GreimersR.HavardL.MervilleM

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The proposed mechanisms behind BPC-157 center on four distinct biological processes, which are the formation of new blood vessels, the reorganization of the extracellular matrix, the proliferation of fibroblasts, and inflammatory regulation

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