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If cell-level selection drives purification of the missense mtDNA variant, we would expect little change in heteroplasmy within ancestry lineages, whereas lineages with high heteroplasmy will drop out in the later timepoint due to their growth defect

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A 2021 randomized controlled trial published in Diabetes Care (N=105) compared dulaglutide 1.5 mg weekly against glimepiride over 24 weeks in adults with type 2 diabetes and found that dulaglutide significantly reduced plasma malondialdehyde (a lipid peroxidation marker) and raised superoxide dismutase activity

Xie J, Hong S, Zhang X, Li Y, Xie R

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