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We call a gene that is unable to perform its job a Dirty Gene

406,407,408 A phase 2 RCT demonstrated that berberine ursodeoxycholate significantly reduced liver fat content, improved glycemic control, lowered liver enzyme levels, and promoted weight loss in T2D patients with presumed NASH

For other ADs, therapeutic potential has mainly been validated in animal or in vitro models, whereas human clinical data remain scarce and limited to small cohorts

J Mol Cell Cardiol 125:185194 Zhong J, Tan Y, Lu J, Liu J, Xiao X, Zhu P et al (2019) Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: a novel mechanism linking Ripk3-modified mitochondrial performance and Endoplasmic reticulum function