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Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID-19Mechanisms and Therapeutic Targets

Food Research International, 175 , 113716

In addition, compounds targeting mitochondrial nitric oxide radicals can effectively inhibit ferroptosis in various cells, indicating that mitochondrial lipid peroxidation plays a key role in ferroptotic OS (Krainz et al., 2016)

The formation of methemoglobin from hemoglobin within red cells is an ongoing oxidative process that results from exposure of hemoglobin to a variety of highly reactive molecules (oxygen free radicals), produced during normal cell metabolism [4]

283,286 Blockade of GM-CSF Several studies have reported the protective roles of GM-CSF in the early stage of infection, 294,295,296 and numerous clinical trials of human recombinant GM-CSF including sargramostim and molgramostim have been registered for the treatment of COVID-19

This decrease in GCL expression directly affects glutathione synthesis, probably related to the observed increase in transforming growth factor (TGF-) levels in patients with Type 2 diabetes ( In general, glutathione plays a crucial role as an antioxidant in protecting the body from oxidative stress