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It has also been reported that VEGF alters the expression and distribution of TJs proteins, leading to BBB hyperpermeability in hypoxia and autoimmune encephalomyelitis (Zhang et al., 2000)

Moreover, the abundance of GSH (110 mmol L 1 ) might favour the spontaneous reaction between GSH and FA, which, if not limited, could alter the GSH:GSSG ratio leading to oxidative stress

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These results were in line with our IPA analysis showing inactivity of NAD signalling (Fig

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