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A good clinical trial today is grounded in science, provides benefits to patients that should outweigh any risks, and treats patients with respect

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The molecular mechanisms that promote the deleterious effects of alcohol metabolism to cause ARLD are intricate and multifactorial and include disruption of lipid and methionine metabolism, alterations in mitochondrial dynamics, respiration, membrane structure, mtDNA oxidation, and ROS production [69], whose final impact in ARLD onset is determined by genetic and environmental factors

doi: 10.3390/cells10081976 69 QuadrosEV

Limited data from clinical trials are available in this regard